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Structure of 887587-18-0
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Tert-butyl 4-(piperazine-1-carbonyl)piperidine-1-carboxylate is a bifunctional building block featuring a piperazine ring tethered to a piperidine core via a carbonyl linker. This structure integrates a protected amine and a flexible, electron-rich heterocyclic system, enabling efficient incorporation into complex scaffolds. The tert-butyl ester group offers stability under basic conditions while permitting straightforward deprotection. The molecule's solubility in common organic solvents and robustness in multistep synthesis streamline its use in medicinal chemistry campaigns targeting CNS-active compounds and kinase inhibitors.
Tert-butyl 4-(piperazine-1-carbonyl)piperidine-1-carboxylate serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient construction of complex piperazine-containing scaffolds. The tert-butyl carbamate group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. The piperazine moiety offers multiple points for functionalization, while the piperidine core supports diverse transformations, including alkylation, acylation, and transition-metal-catalyzed coupling reactions, making it ideal for library synthesis and lead optimization workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: