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Structure of 88912-25-8
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4,6-Dichloropicolinic acid is a bench-stable, electron-deficient heterocyclic carboxylic acid featuring two chlorine substituents at the 4- and 6-positions of the pyridine ring. This configuration enhances its utility in transition metal-catalyzed coupling reactions and as a building block for bioactive heterocycles. The molecule integrates readily into pharmaceutical scaffolds due to its polar, rigid framework and favorable reactivity profile under standard conditions.
4,6-Dichloropicolinic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds via cyclization or coupling reactions. Its dual chlorine substituents enhance electrophilicity at the pyridine ring, facilitating nucleophilic substitution and transition-metal-catalyzed functionalization. The carboxylic acid group provides a handle for derivatization, including amide formation and esterification, while the compound exhibits good bench stability and ease of purification—key attributes for scalable synthesis and process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: