5-Chloro-2,3-difluoropyridine

Name: 5-Chloro-2,3-difluoropyridine
Brand: ChemScene
Availability: InStock
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CAS No. 89402-43-7
Cat. No. CS-W003144
Purity≥95%
MDL No.MFCD04039314

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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5-Chloro-2,3-difluoropyridine|CS-W003144

Structure of 89402-43-7

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Description

5-Chloro-2,3-difluoropyridine is a fluorinated heterocycle featuring strategically positioned halogens enabling selective cross-coupling and electrophilic substitution. This electron-deficient pyridine derivative facilitates efficient C–H functionalization and serves as a key scaffold in agrochemical and pharmaceutical synthesis. The ortho-fluoro substituents enhance reactivity while maintaining stability under standard conditions.

Application

5-Chloro-2,3-difluoropyridine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling. Its orthogonal reactivity profile—driven by the electron-deficient pyridine ring and strategically positioned halogens—facilitates selective substitution under mild conditions. The molecule exhibits excellent bench stability and compatibility with diverse functional groups, making it ideal for constructing complex heterocyclic scaffolds in API development.

General Information

CAS No. 89402-43-7
Cat. No. CS-W003144
Purity ≥95%
MDL No. MFCD04039314
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₂ClF₂N
Molecular Weight 149.53
Synonym(s) 2,3-Difuoro-5-chloropyridine
SMILES FC1=CC(Cl)=CN=C1F

Computational Chemistry Data

TPSA 12.89
LogP 2.0132
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS02,GHS07
Signal Word : Danger	UN#: 1993
Class : 3	Packing Group : Ⅲ
Hazard Statements : H226-H302-H412
Precautionary Statements : P210-P233-P240-P241-P273

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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5-Chloro-2,3-difluoropyridine

CAS No. 89402-43-7

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