2-Chloro-4-methyl-6-(methylthio)pyrimidine

Name: 2-Chloro-4-methyl-6-(methylthio)pyrimidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 89466-59-1
Cat. No. CS-0044840
Purity≥96%
MDL No.MFCD09832937

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-4-methyl-6-(methylthio)pyrimidine|CS-0044840

Structure of 89466-59-1

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General Information

CAS No. 89466-59-1
Cat. No. CS-0044840
Purity ≥96%
MDL No. MFCD09832937
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇ClN₂S
Molecular Weight 174.65
Synonym(s) 2-chloro-4-Methylthio-6-methylpyrimidine
SMILES CSC1=CC(C)=NC(Cl)=N1

Description

2-Chloro-4-methyl-6-(methylthio)pyrimidine features a pyrimidine core functionalized with chlorine, methyl, and methylthio groups, enabling selective reactivity in heterocyclic synthesis. This electron-deficient scaffold integrates readily into pharmaceutical intermediates and agrochemical building blocks, offering enhanced stability under standard conditions.

Application

2-Chloro-4-methyl-6-(methylthio)pyrimidine serves as a versatile pyrimidine building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through nucleophilic substitution. The chloro group at C2 facilitates reliable coupling with amines, thiols, and other nucleophiles under mild conditions, while the methylthio substituent enhances reactivity and provides a handle for further functionalization. Bench-stable and easily purified, it functions effectively in standard synthetic workflows for API development and library synthesis.

Synthesis

Route1
- 16710-11-5
- ~%
- In-stock
  
  89466-59-1
References
- DE839640 , ; DRP/DRBP Org.Chem. GB658202 , ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 25.78
LogP 2.16032
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2-Chloro-4-methyl-6-(methylthio)pyrimidine

CAS No. 89466-59-1

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