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Structure of 895534-38-0
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6,8-Difluoro-3,4-dihydro-2H-naphthalen-1-one features a fluorinated naphthalenone core with enhanced electron-withdrawing character due to the ortho-fluorine substituents. This structure imparts improved metabolic stability and modulates electronic properties for use in bioactive molecule design. The compound serves as a key scaffold in medicinal chemistry, particularly for kinase inhibitors and CNS-targeted therapeutics.
6,8-Difluoro-3,4-dihydro-2H-naphthalen-1-one serves as a versatile fluorinated building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its electron-deficient aromatic core enables efficient Suzuki-Miyaura and Buchwald-Hartwig couplings, while the difluoro substitution enhances metabolic stability and modulates lipophilicity. Bench-stable and readily purified by flash chromatography, it functions effectively in multi-step syntheses requiring ortho-functionalized naphthalene scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: