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CS-W001157 4
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(S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one hydrochloride Rivaroxaban Impurity

  • CAS No. 898543-06-1

  • Cat. No. CS-0169475
  • Purity≥98%
  • MDL No.MFCD20133901

*For research and further manufacturing use only, not for direct human use.

(S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one hydrochloride Rivaroxaban Impurity|CS-0169475

Structure of 898543-06-1

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General Information

  • CAS No. 898543-06-1
  • Cat. No. CS-0169475
  • Purity ≥98%
  • MDL No. MFCD20133901
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₈ClN₃O₄
  • Molecular Weight 327.77
  • Synonym(s) 4-[4-[(5S)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone hydrochloride
  • SMILES O=C1N(C2=CC=C(N3C(O[C@@H](CN)C3)=O)C=C2)CCOC1.[H]Cl

Synthesis

  • Route1
    • (S)-4-(4-((3-amino-2-hydroxypropyl)amino)phenyl)morpholin-3-one hydrochloride  Rivaroxaban Impurity|CS-0165643
      1403383-55-0
    • null|null
      530-62-1
    • ~79%
    • (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one hydrochloride Rivaroxaban Impurity|CS-0169475
      898543-06-1

    References

    • SANDOZ AG; STURM, Hubert; KNEPPER, Kerstin Patent: WO2012/140061 A1, 2012 ; Location in patent: Page/Page column 36 ;
  • Route2
    • null|null
      1403383-52-7
    • ~34%
    • (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one hydrochloride Rivaroxaban Impurity|CS-0169475
      898543-06-1

    References

    • SANDOZ AG; STURM, Hubert; KNEPPER, Kerstin Patent: WO2012/140061 A1, 2012 ; Location in patent: Page/Page column 30 ;
  • Route3
    • null|null
      1416129-92-4
    • ~%
    • (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one hydrochloride Rivaroxaban Impurity|CS-0169475
      898543-06-1

    References

    • SYMED LABS LIMITED; MOHAN RAO, Dodda; KRISHNA REDDY, Pingili; VENKAT REDDY, Buthukuri Patent: WO2013/46211 A1, 2013 ; Location in patent: Page/Page column 63 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   85.1
  • LogP   0.7555
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   3

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