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6-Bromoquinazoline

  • CAS No. 89892-21-7

  • Cat. No. CS-D1650
  • Molecule weight209.04
  • Purity≥97%
  • MDL No.MFCD08236695

*For research and further manufacturing use only, not for direct human use.

6-Bromoquinazoline|CS-D1650

Structure of 89892-21-7

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General Information

  • CAS No. 89892-21-7
  • Cat. No. CS-D1650
  • Purity ≥97%
  • MDL No. MFCD08236695
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrN₂
  • Molecular Weight 209.04
  • Synonym(s) 6-Bromoquizoline
  • SMILES BrC1=CC2=CN=CN=C2C=C1

Description

6-Bromoquinazoline serves as a key heterocyclic scaffold for medicinal chemistry and materials science. This brominated quinazoline derivative features a reactive halogen at the 6-position, enabling facile cross-coupling transformations. The electron-deficient core supports efficient integration into kinase inhibitors and organic semiconductors, offering enhanced stability under standard conditions.

Application

6-Bromoquinazoline serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for the construction of biologically active quinazoline derivatives. Its bromine substituent facilitates efficient C–C and C–heteroatom bond formation under standard conditions, offering high functional group tolerance and bench stability. This compound functions as a key scaffold for developing kinase inhibitors and other pharmaceutical intermediates through well-established synthetic protocols.

Synthesis

  • Route1

    References

    • US2006/35897 A1, ; Page/Page column 20 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.3923
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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