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Structure of 89976-12-5
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1-Methyl-4-nitro-2-(trifluoromethyl)benzene features a trifluoromethyl group flanking a nitro-substituted aromatic ring, delivering enhanced electron-withdrawal and metabolic stability. This combination enables direct incorporation into C–H functionalization cascades and transition-metal-catalyzed cross-coupling reactions under standard conditions. The methyl group provides a convenient handle for further derivatization, while the molecule exhibits excellent bench stability and solubility in common organic solvents.
1-Methyl-4-nitro-2-(trifluoromethyl)benzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of substituted aromatic scaffolds. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the nitro and methyl functionalities provide orthogonal handles for sequential functionalization. The compound exhibits excellent bench stability and facilitates diverse transformations including reduction, coupling reactions, and electrophilic substitution, making it valuable for rapid lead optimization and process-scale applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: