4-Bromo-2,6-difluoropyridine

Name: 4-Bromo-2,6-difluoropyridine
Brand: ChemScene
Availability: InStock
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CAS No. 903513-58-6
Cat. No. CS-W006889
Purity≥97%
MDL No.MFCD21603855

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 903513-58-6

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Description

4-Bromo-2,6-difluoropyridine is a fluorinated heterocyclic building block featuring orthogonal reactivity at the bromo and difluoro positions. This electron-deficient pyridine enables selective cross-coupling and nucleophilic substitution under standard conditions, delivering access to diverse pharmaceutical intermediates with enhanced metabolic stability.

Application

4-Bromo-2,6-difluoropyridine serves as a versatile building block in medicinal chemistry and cross-coupling synthesis. The bromo group enables palladium-catalyzed coupling reactions, while the ortho-fluorine atoms enhance reactivity in nucleophilic aromatic substitution. Its bench-stable nature and compatibility with diverse functional groups make it well-suited for constructing complex heterocyclic scaffolds in API development.

General Information

CAS No. 903513-58-6
Cat. No. CS-W006889
Purity ≥97%
MDL No. MFCD21603855
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₂BrF₂N
Molecular Weight 193.98
Synonym(s) 2,6-difluoro-4-bromopyridine
SMILES FC1=CC(Br)=CC(F)=N1

Computational Chemistry Data

TPSA 12.89
LogP 2.1223
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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4-Bromo-2,6-difluoropyridine

CAS No. 903513-58-6

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