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CS-W001157 4
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2-(4-Chlorophenyl)cyclopropanecarboxylic acid

  • CAS No. 90940-40-2

  • Cat. No. CS-0035601
  • Purity≥97%
  • MDL No.MFCD03419437

*For research and further manufacturing use only, not for direct human use.

2-(4-Chlorophenyl)cyclopropanecarboxylic acid|CS-0035601

Structure of 90940-40-2

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General Information

  • CAS No. 90940-40-2
  • Cat. No. CS-0035601
  • Purity ≥97%
  • MDL No. MFCD03419437
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉ClO₂
  • Molecular Weight None
  • Synonym(s) trans-2-(4-chlorophenyl)cyclopropane-1-carboxylic acid
  • SMILES C1=C(C=CC(=C1)Cl)C2CC2C(=O)O

Description

This cyclopropanecarboxylic acid derivative features a 4-chlorophenyl group at the 2-position, imparting enhanced lipophilicity and metabolic stability. The strained cyclopropane ring enables unique conformational restraint, while the carboxylic acid moiety facilitates direct coupling or derivatization in medicinal chemistry campaigns.

Application

2-(4-Chlorophenyl)cyclopropanecarboxylic acid serves as a valuable building block in medicinal chemistry, offering a rigid cyclopropyl scaffold with ortho-substituted aryl functionality. Its carboxylic acid group enables straightforward derivatization into amides, esters, and acyl chlorides, facilitating incorporation into diverse molecular architectures. The molecule exhibits excellent bench stability and functional group tolerance, supporting its use in standard coupling reactions and heterocycle synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.5281
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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