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CS-W001157 4
Total: USD 88.00

2,4-Dimethoxybenzoic acid

  • CAS No. 91-52-1

  • Cat. No. CS-W019954
  • Purity≥97%
  • MDL No.MFCD00002434

*For research and further manufacturing use only, not for direct human use.

2,4-Dimethoxybenzoic acid|CS-W019954

Structure of 91-52-1

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General Information

  • CAS No. 91-52-1
  • Cat. No. CS-W019954
  • Purity ≥97%
  • MDL No. MFCD00002434
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀O₄
  • Molecular Weight 182.17
  • Synonym(s) 2,4-Dimethoxybenzoic acid; Benzoic acid, 2,4-dimethoxy-
  • SMILES O=C(O)C1=CC=C(OC)C=C1OC

Description

2,4-Dimethoxybenzoic acid features a benzoic acid core substituted with methoxy groups at the 2- and 4-positions, delivering enhanced solubility and stability in polar solvents. This electron-rich scaffold enables efficient coupling reactions in synthetic organic chemistry and serves as a key building block for pharmaceutical intermediates and functional materials.

Application

2,4-Dimethoxybenzoic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, offering predictable reactivity in esterification, amidation, and Suzuki-Miyaura coupling reactions. The ortho-dimethoxy substitution pattern enhances solubility and stability under standard reaction conditions, while the carboxylic acid group enables straightforward derivatization. Its well-defined spectral characteristics and bench-stable nature facilitate efficient purification and integration into multi-step synthetic sequences.

Synthesis

  • Route1

    References

    • Dehbashi, Mohsen; Aliahmad, Mousa; Shafiee, Mohammad Reza Mohammad; Ghashang, Majid Phosphorus, Sulfur and Silicon and the Related Elements, 2013 , vol. 188, # 7 p. 864 - 872
  • Route2
    • null|null
      201230-82-2
    • In-stock
      1,3-Dimethoxybenzene|CS-W018510
      151-10-0
    • ~%
    • In-stock
      2,4-Dimethoxybenzoic acid|CS-W019954
      91-52-1

    References

    • Chemical Communications, , # 4 p. 486 - 488
  • Route3

    References

    • Van Otterlo, Willem A. L.; Michael, Joseph P.; De Koning, Charles B. Synthetic Communications, 2007 , vol. 37, # 20 p. 3611 - 3621

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.76
  • LogP   1.402
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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