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CS-W001157 4
Total: USD 88.00

3-Bromo-5-chlorothieno[3,2-b]pyridine

  • CAS No. 912332-40-2

  • Cat. No. CS-0051468
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Bromo-5-chlorothieno[3,2-b]pyridine|CS-0051468

Structure of 912332-40-2

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General Information

  • CAS No. 912332-40-2
  • Cat. No. CS-0051468
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃BrClNS
  • Molecular Weight 248.53
  • Synonym(s) 3-BroMo-5-chloro-thieno[3,2-b]pyridine
  • SMILES ClC1=CC=C2SC=C(Br)C2=N1

Description

3-Bromo-5-chlorothieno[3,2-b]pyridine is a heterocyclic scaffold featuring bromo and chloro substituents at electronically distinct positions, enabling selective cross-coupling reactions. The fused thienopyridine core imparts rigidity and enhanced electron-deficient character, facilitating integration into advanced pharmaceutical intermediates and functional materials.

Application

3-Bromo-5-chlorothieno[3,2-b]pyridine serves as a versatile heterocyclic building block for the synthesis of biologically active compounds. Its complementary halogenation pattern enables sequential cross-coupling reactions, facilitating efficient construction of complex scaffolds. The molecule exhibits excellent bench stability and compatibility with palladium-catalyzed coupling protocols, making it well-suited for medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • ELI LILLY AND COMPANY Patent: WO2006/107784 A1, 2006 ; Location in patent: Page/Page column 104-105 ; WO 2006/107784 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.7122
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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