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Structure of 912457-18-2
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2-Bromo-6-(methoxycarbonyl)benzoic acid features a bromine atom at the 2-position and a methoxycarbonyl group at the 6-position, creating a sterically constrained, electron-deficient aromatic core. This configuration enables direct coupling reactions in late-stage functionalization, particularly in Suzuki-Miyaura and Stille transformations. The carboxylic acid moiety serves as a handle for derivatization via amide or ester formation, facilitating integration into bioactive scaffolds. The molecule exhibits bench-stable handling under standard conditions.
2-Bromo-6-(methoxycarbonyl)benzoic acid serves as a versatile building block in the synthesis of substituted benzoic acid derivatives and heterocyclic scaffolds. Its orthogonal functionality—bromine for cross-coupling and ester for selective hydrolysis or derivatization—enables efficient access to complex molecular architectures. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: