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Structure of 91407-41-9
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5-Fluoro-2-hydroxybenzonitrile features a fluorine atom at the meta position relative to the hydroxyl group, creating a uniquely polarized aromatic system. The para-oriented nitrile and phenolic hydroxyl groups enable strong hydrogen bonding and enhanced solubility in polar solvents. This combination imparts high reactivity in nucleophilic substitution and coupling reactions. The compound exhibits bench-stable behavior under standard conditions and serves as a key intermediate in the synthesis of bioactive heterocycles and functionalized dyes.
5-Fluoro-2-hydroxybenzonitrile serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the phenolic hydroxyl and nitrile groups. Its ortho-substituted architecture facilitates regioselective derivatization, while the fluorine atom enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and compatibility with standard coupling and protection protocols, making it suitable for synthesizing bioactive heterocycles and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: