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CS-W001157 4
Total: USD 88.00

2-(Hydroxymethyl)isonicotinic acid

  • CAS No. 915140-06-6

  • Cat. No. CS-0099794
  • Purity≥95%
  • MDL No.MFCD11977439

*For research and further manufacturing use only, not for direct human use.

2-(Hydroxymethyl)isonicotinic acid|CS-0099794

Structure of 915140-06-6

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General Information

  • CAS No. 915140-06-6
  • Cat. No. CS-0099794
  • Purity ≥95%
  • MDL No. MFCD11977439
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₃
  • Molecular Weight 153.14
  • Synonym(s) 2-Hydroxymethylisonicotinic acid
  • SMILES O=C(C1=CC(CO)=NC=C1)O

Description

2-(Hydroxymethyl)isonicotinic acid features a pyridine ring bearing both carboxylic acid and hydroxymethyl functional groups at the 2- and 6-positions, respectively. This arrangement enables direct incorporation into bioconjugation workflows, where the hydroxyl group serves as a site for derivatization or metal chelation. The molecule exhibits enhanced solubility in aqueous systems compared to related aromatic acids, facilitating use in biological assay development and peptide synthesis.

Application

2-(Hydroxymethyl)isonicotinic acid serves as a versatile building block for bioactive heterocycles and pharmaceutical intermediates. Its pyridine core enables facile derivatization, while the pendant hydroxymethyl group offers direct access to aldehyde or carboxylic acid functionalities via oxidation. The molecule exhibits good bench stability and compatibility with standard coupling and protection protocols, facilitating integration into multistep synthetic sequences for API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   70.42
  • LogP   0.2721
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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