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CS-W001157 4
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Ethyl 2-(2-chloropyrimidin-5-yl)acetate

  • CAS No. 917025-00-4

  • Cat. No. CS-0049540
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

Ethyl 2-(2-chloropyrimidin-5-yl)acetate|CS-0049540

Structure of 917025-00-4

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Description

Ethyl 2-(2-chloropyrimidin-5-yl)acetate features a chlorinated pyrimidine core linked to an ethyl acrylate moiety, enabling direct incorporation into heterocyclic scaffolds. This electrophilic building block facilitates C–C bond formation under mild conditions, offering high reactivity in cross-coupling and nucleophilic substitution processes. The molecule exhibits excellent stability and solubility in common organic solvents, simplifying handling during synthetic workflows.

Application

Ethyl 2-(2-chloropyrimidin-5-yl)acetate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to pyrimidine-based scaffolds through nucleophilic substitution and coupling reactions. The electrophilic chloro group at the 2-position facilitates robust functionalization under mild conditions, while the ester moiety supports further derivatization. Its bench-stable nature and compatibility with standard synthetic workflows make it ideal for medicinal chemistry campaigns and API intermediate development.

General Information

  • CAS No. 917025-00-4
  • Cat. No. CS-0049540
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉ClN₂O₂
  • Molecular Weight 200.62
  • Synonym(s) ethyl 2‐(2‐chloropyriMidin‐5‐yl)acetate
  • SMILES CCOC(=O)CC1=CN=C(Cl)N=C1

Computational Chemistry Data

  • TPSA   52.08
  • LogP   1.2356
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   3

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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