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Structure of 918487-09-9
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4-Iodo-1-isobutyl-1H-pyrazole is a bench-stable, moisture-tolerant heterocyclic building block featuring a reactive iodine handle at the 4-position and a sterically hindered isobutyl group at nitrogen. This combination enables efficient late-stage functionalization via cross-coupling reactions while maintaining structural integrity under standard conditions.
4-Iodo-1-isobutyl-1H-pyrazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable iodo substituent. The isobutyl group provides favorable lipophilicity and metabolic stability, while the pyrazole core offers hydrogen-bonding capacity and structural rigidity. This compound exhibits excellent bench stability, facilitates straightforward purification, and functions reliably in Suzuki-Miyaura and Negishi couplings for constructing complex heterocyclic scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: