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Structure of 91940-84-0
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2-tert-Butyl-isonicotinic acid features a sterically hindered tert-butyl group at the 2-position of the isonicotinic acid scaffold, enhancing metabolic stability and modulating electronic properties. This structural configuration imparts improved lipophilicity and resistance to oxidative degradation, making it valuable for medicinal chemistry applications where enhanced bioavailability and target selectivity are required.
2-tert-Butyl-isonicotinic acid serves as a versatile building block in medicinal chemistry, offering a sterically hindered pyridine carboxylic acid scaffold with enhanced metabolic stability. Its ortho-tert-butyl group confers improved solubility and resistance to oxidative degradation, enabling reliable coupling reactions in peptide and macrocyclic synthesis. The carboxylic acid functionality facilitates direct amidation, esterification, or metal-catalyzed transformations, supporting efficient access to diverse heterocyclic scaffolds and API intermediates under standard bench conditions.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: