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CS-W001157 4
Total: USD 88.00

4-Phenylmorpholine

  • CAS No. 92-53-5

  • Cat. No. CS-W014318
  • Molecule weight163.22
  • Purity≥98%
  • MDL No.MFCD00006166

*For research and further manufacturing use only, not for direct human use.

4-Phenylmorpholine|CS-W014318

Structure of 92-53-5

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General Information

  • CAS No. 92-53-5
  • Cat. No. CS-W014318
  • Purity ≥98%
  • MDL No. MFCD00006166
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃NO
  • Molecular Weight 163.22
  • Synonym(s) PHENYLMORPHOLINE,N-
  • SMILES C1=CC=CC=C1N2CCOCC2

Description

4-Phenylmorpholine is a versatile heterocyclic compound featuring a morpholine ring fused to a phenyl group, delivering enhanced electron-donating capacity and improved solubility. This structure supports integration into pharmaceutical intermediates and functional materials, where its aromaticity and basic nitrogen facilitate tailored reactivity in synthetic pathways.

Application

4-Phenylmorpholine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles due to its stable, electron-rich morpholine core. Its phenyl substituent enhances π-stacking potential and modulates lipophilicity, while the nitrogen functionality offers moderate basicity and hydrogen-bonding capacity. The compound exhibits good bench stability and compatibility with standard coupling and functionalization protocols, facilitating efficient synthesis of pharmaceutical intermediates and targeted scaffolds.

Synthesis

  • Route1
    • null|null
      110-91-8
    • null|null
      66950-63-8
    • ~98%
    • In-stock
      4-Phenylmorpholine|CS-W014318
      92-53-5

    References

    • Ackermann, Lutz; Sandmann, Rene; Song, Weifeng Organic Letters, 2011 , vol. 13, # 7 p. 1784 - 1786
  • Route2
    • null|null
      110-91-8
    • Phenyl diethylcarbamate|CS-0574627
      65009-00-9
    • ~10%
    • In-stock
      4-Phenylmorpholine|CS-W014318
      92-53-5

    References

    • Shimasaki, Toshiaki; Tobisu, Mamoru; Chatani, Naoto Angewandte Chemie - International Edition, 2010 , vol. 49, # 16 p. 2929 - 2932
  • Route3
    • null|null
      110-91-8
    • null|null
      108-90-7
    • ~10%
    • In-stock
      4-Phenylmorpholine|CS-W014318
      92-53-5

    References

    • Chen, Chen; Yang, Lian-Ming Journal of Organic Chemistry, 2007 , vol. 72, # 16 p. 6324 - 6327

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H311
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.47
  • LogP   1.5232
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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