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Structure of 927434-20-6
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2-Iodo-3-(trifluoromethyl)pyridine features a reactive iodide at the 2-position paired with a strongly electron-withdrawing trifluoromethyl group at the 3-position, enabling efficient cross-coupling reactions. This configuration enhances regioselectivity in palladium-catalyzed transformations and improves stability under standard handling conditions.
2-Iodo-3-(trifluoromethyl)pyridine serves as a versatile building block in cross-coupling chemistry, enabling efficient Suzuki, Stille, and Negishi reactions due to its well-defined reactivity profile. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the iodine moiety provides high functional group tolerance and reliable coupling efficiency. This compound exhibits excellent bench stability and is readily purified by flash chromatography, making it ideal for medicinal chemistry campaigns and API intermediate synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H320-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: