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CS-W001157 4
Total: USD 88.00

4-Chlorobutan-1-ol

  • CAS No. 928-51-8

  • Cat. No. CS-0022417
  • Purity≥80%
  • MDL No.MFCD00002967

*For research and further manufacturing use only, not for direct human use.

4-Chlorobutan-1-ol|CS-0022417

Structure of 928-51-8

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General Information

  • CAS No. 928-51-8
  • Cat. No. CS-0022417
  • Purity ≥80%
  • MDL No. MFCD00002967
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₉ClO
  • Molecular Weight 108.57
  • Synonym(s) Tetramethylene Chlorohydrin (contains varying amounts of Tetrahydrofuran)
  • SMILES OCCCCCl

Description

4-Chloro-1-butanol, an alkylating agent, is one of the genotoxic impurity in active pharmaceutical ingredients. Reaction of 4-chloro-1-butanol and Reichardts dye has been monitored spectrophotometrically for the determination of genotoxic impurities in pharmaceuticals.4-Chloro-1-butanol was employed as an internal standard in the analysis of genotoxic impurities in active pharmaceutical ingredients by GC-MS technique.

Synthesis

  • Route1
    • null|null
      109-99-9
    • ~82%
    • In-stock
      4-Chlorobutan-1-ol|CS-0022417
      928-51-8

    References

    • Kovalev, B. G.; Matveeva, E. D.; Stan, V. V.; Vovk, G. A.; Yudin, L. G.; Kost, A. N. Journal of Organic Chemistry USSR (English Translation), 1980 , vol. 16, # 10 p. 1728 - 1733 Zhurnal Organicheskoi Khimii, 1980 , vol. 16, # 10 p. 2032 - 2038
  • Route2
    • 2-(4-Chlorobutoxy)tetrahydro-2H-pyran|CS-0148485
      41302-05-0
    • ~85%
    • In-stock
      4-Chlorobutan-1-ol|CS-0022417
      928-51-8

    References

    • Marko, Istvan E.; Ates, Ali; Augustyns, Benoit; Gautier, Arnaud; Quesnel, Yannick; Turet, Laurent; Wiaux, Marianne Tetrahedron Letters, 1999 , vol. 40, # 30 p. 5613 - 5616
  • Route3
    • null|null
      110-63-4
    • ~35%
    • In-stock
      4-Chlorobutan-1-ol|CS-0022417
      928-51-8

    References

    • Lermer, Leonard; Neeland, Edward G.; Ounsworth, James P.; Sims, Russell J.; Tischler, Samuel A.; Weiler, Larry Canadian Journal of Chemistry, 1992 , vol. 70, # 5 p. 1427 - 1445

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05,GHS07,GHS08
Signal Word : Danger
UN#: 2924
Class : 3 (8)
Packing Group : Ⅲ
Hazard Statements : H226-H290-H302-H315-H319-H335-H351
Precautionary Statements : P210-P233-P234-P240-P241-P242-P243-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P390

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   0.9977
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   3

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