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Structure of 928-90-5
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5-Hexyn-1-ol was used in synthesis of:cinnoline-fused cyclic enediynellycopodium alkaloids, (+)-nankakurine A and (+)-nankakurine B7-benzoyloxy-3-(2-nitrophenylseleno)-1,5-cyclodecadiyne
Hex-5-yn-1-ol serves as a versatile terminal alkyne building block for transition-metal-catalyzed coupling reactions, including Sonogashira and Glaser-type homocoupling. Its primary alcohol functionality enables straightforward derivatization via esterification or protection, while the terminal alkyne facilitates efficient conjugation with aryl halides and other electrophiles. The molecule exhibits good bench stability and is readily purified by distillation or silica gel chromatography, making it well-suited for iterative synthesis in medicinal chemistry and materials science applications.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: