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CS-W001157 4
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3-Fluoropyrazine-2-carboxylic acid

  • CAS No. 929022-78-6

  • Cat. No. CS-0503587
  • Molecule weight142.09
  • Purity≥97%
  • MDL No.MFCD22481006

*For research and further manufacturing use only, not for direct human use.

3-Fluoropyrazine-2-carboxylic acid|CS-0503587

Structure of 929022-78-6

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General Information

  • CAS No. 929022-78-6
  • Cat. No. CS-0503587
  • Purity ≥97%
  • MDL No. MFCD22481006
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃FN₂O₂
  • Molecular Weight 142.09
  • Synonym(s) None
  • SMILES OC(=O)C1=NC=CN=C1F

Description

3-Fluoropyrazine-2-carboxylic acid features a fluorinated pyrazine core paired with a carboxylic acid group, enabling direct incorporation into bioactive scaffolds. The electron-deficient ring facilitates nucleophilic substitution and enhances metabolic stability in drug discovery applications. This bench-stable, moisture-tolerant reagent integrates readily into medicinal chemistry campaigns requiring heteroaromatic building blocks.

Application

3-Fluoropyrazine-2-carboxylic acid serves as a versatile building block for the synthesis of heterocyclic scaffolds in medicinal chemistry. Its fluorinated pyrazine core provides enhanced metabolic stability and modulates electronic properties, while the carboxylic acid group enables direct amidation, esterification, or coupling reactions. The compound exhibits good bench stability and facilitates efficient functionalization, making it suitable for iterative library synthesis and API development.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501

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Computational Chemistry Data

  • TPSA   63.08
  • LogP   0.3139
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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