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CS-W001157 4
Total: USD 88.00

N-Methylvalerolactam

  • CAS No. 931-20-4

  • Cat. No. CS-0222604
  • Purity≥95%
  • MDL No.MFCD00006555

*For research and further manufacturing use only, not for direct human use.

N-Methylvalerolactam|CS-0222604

Structure of 931-20-4

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General Information

  • CAS No. 931-20-4
  • Cat. No. CS-0222604
  • Purity ≥95%
  • MDL No. MFCD00006555
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁NO
  • Molecular Weight 113.16
  • Synonym(s) 1-Methyl-2-piperidinone
  • SMILES O=C1N(CCCC1)C

Description

1-Methylpiperidin-2-one is a bench-stable, nitrogen-rich heterocycle featuring a ketone functionality at the 2-position and a methyl group on the nitrogen. This structure integrates readily into medicinal chemistry scaffolds, offering enhanced solubility and metabolic stability in bioactive molecule design.

Application

1-Methylpiperidin-2-one serves as a versatile scaffold in medicinal chemistry, enabling efficient access to nitrogen-containing heterocycles through standard functional group transformations. Its amide functionality and tertiary amine center offer favorable reactivity for alkylation, reduction, and coupling reactions, while the molecule exhibits good bench stability and ease of purification. Widely utilized in API synthesis, it functions as a key building block for bioactive compounds requiring controlled polarity and metabolic stability.

Synthesis

  • Route1
    • null|null
      6066-89-3
    • ~98%
    • In-stock
      N-Methylvalerolactam|CS-0222604
      931-20-4

    References

    • Murahashi, Shun-Ichi; Naota, Takeshi; Saito, Eiichiro Journal of the American Chemical Society, 1986 , vol. 108, # 24 p. 7846 - 7847
  • Route2

    References

    • Lunn, George; Sansone, Eric B. Journal of Organic Chemistry, 1986 , vol. 51, # 4 p. 513 - 517
  • Route3
    • In-stock
      2-Piperidone|CS-W022933
      675-20-7
    • null|null
      74-88-4
    • ~61%
    • In-stock
      N-Methylvalerolactam|CS-0222604
      931-20-4

    References

    • Goumri-Magnet; Guerret; Gornitzka; Cazaux; Bigg; Palacios; Bertrand Journal of Organic Chemistry, 1999 , vol. 64, # 10 p. 3741 - 3744

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.31
  • LogP   0.6287
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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