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CS-W001157 4
Total: USD 88.00

N-Acetyl-2-pyrrolidone

  • CAS No. 932-17-2

  • Cat. No. CS-0186313
  • Purity≥97%
  • MDL No.MFCD00014101

*For research and further manufacturing use only, not for direct human use.

N-Acetyl-2-pyrrolidone|CS-0186313

Structure of 932-17-2

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General Information

  • CAS No. 932-17-2
  • Cat. No. CS-0186313
  • Purity ≥97%
  • MDL No. MFCD00014101
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉NO₂
  • Molecular Weight 127.14
  • Synonym(s) None
  • SMILES O=C(N1C(=O)CCC1)C

Description

1-Acetylpyrrolidin-2-one is a stable, moisture-tolerant heterocyclic ketone featuring a fused five-membered ring with a pendant acetyl group. This compound integrates readily into synthetic sequences requiring polar, electron-deficient scaffolds and serves as a key intermediate in the construction of bioactive nitrogen-containing molecules.

Application

1-Acetylpyrrolidin-2-one serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrrolidine-based scaffolds. Its acetyl group enhances functional group tolerance and facilitates downstream transformations such as reductive amination and nucleophilic substitution. The compound exhibits good bench stability and ease of purification, making it well-suited for high-throughput synthesis workflows and API intermediate development.

Synthesis

  • Route1

    References

    • Masui, Masaichiro; Hara, Seijiro; Ozaki, Shigeko Chemical & Pharmaceutical Bulletin, 1986 , vol. 34, # 3 p. 975 - 979
  • Route2
    • In-stock
      5-Methoxy-3,4-dihydro-2H-pyrrole|CS-W022401
      5264-35-7
    • null|null
      201230-82-2
    • ~96%
    • In-stock
      N-Acetyl-2-pyrrolidone|CS-0186313
      932-17-2

    References

    • Xu, Hongyu; Jia, Li Organic Letters, 2003 , vol. 5, # 21 p. 3955 - 3957
  • Route3
    • null|null
      183208-72-2
    • ~40%
    • In-stock
      N-Acetyl-2-pyrrolidone|CS-0186313
      932-17-2

    References

    • Doan, Huynh Dong; Gore, Jacques; Vatele, Jean-Michel Tetrahedron Letters, 1999 , vol. 40, # 37 p. 6765 - 6768

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.38
  • LogP   0.1553
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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