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CS-W001157 4
Total: USD 88.00

3,5-Dimethyl-1H-pyrazole-1-carboxamide

  • CAS No. 934-48-5

  • Cat. No. CS-0319030
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3,5-Dimethyl-1H-pyrazole-1-carboxamide|CS-0319030

Structure of 934-48-5

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General Information

  • CAS No. 934-48-5
  • Cat. No. CS-0319030
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉N₃O
  • Molecular Weight 139.16
  • Synonym(s) 1-Carbamoyl-3,5-dimethylpyrazole
  • SMILES CC1=NN(C(N)=O)C(C)=C1

Description

3,5-Dimethyl-1H-pyrazole-1-carboxamide features a sterically hindered pyrazole core with complementary methyl and amide functionalities, enabling robust integration into medicinal chemistry scaffolds. This bench-stable compound delivers enhanced metabolic resistance and favorable solubility profiles in polar solvents, streamlining synthetic access to bioactive heterocycles.

Application

3,5-Dimethyl-1H-pyrazole-1-carboxamide serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of pyrazole-based scaffolds with enhanced metabolic stability. Its carboxamide group facilitates diverse functionalization and hydrogen bonding interactions, while the methyl substituents improve lipophilicity and steric shielding. The compound exhibits excellent bench stability and compatibility with standard coupling reactions, making it well-suited for parallel synthesis campaigns and API intermediate development.

Synthesis

  • Route1
    • In-stock
      Semicarbazide hydrochloride|CS-W018530
      563-41-7
    • null|null
      123-54-6
    • ~90%
    • In-stock
      3,5-Dimethyl-1H-pyrazole-1-carboxamide|CS-0319030
      934-48-5

    References

    • Ali, Sh. Shaukat; Ashraf, C. M.; Younas, M.; Ehsan, A. Pakistan Journal of Scientific and Industrial Research, 1993 , vol. 36, # 12 p. 502 - 510
  • Route2
    • null|null
      112423-54-8
    • ~85%
    • In-stock
      3,5-Dimethyl-1H-pyrazole-1-carboxamide|CS-0319030
      934-48-5

    References

    • Boettcher, Andreas; Debaerdemaeker, Tony; Radziszewski, Juliusz G.; Friedrichsen, Willy Chemische Berichte, 1988 , vol. 121, p. 895 - 908
  • Route3

    References

    • Alberola, Angel; Calvo, Luis; Ortega, Alfonso Gonzalez; Sadaba, M. Luisa; Sanudo, M. Carmen; Granda, Santiago Garcia; Rodriguez, Elena Garcia Heterocycles, 1999 , vol. 51, # 11 p. 2675 - 2686

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   60.91
  • LogP   0.42674
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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