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CS-W001157 4
Total: USD 88.00

6-Methylpicolinic acid

  • CAS No. 934-60-1

  • Cat. No. CS-W002139
  • Molecule weight137.14
  • Purity≥97%
  • MDL No.MFCD00023481

*For research and further manufacturing use only, not for direct human use.

6-Methylpicolinic acid|CS-W002139

Structure of 934-60-1

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General Information

  • CAS No. 934-60-1
  • Cat. No. CS-W002139
  • Purity ≥97%
  • MDL No. MFCD00023481
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₂
  • Molecular Weight 137.14
  • Synonym(s) 6-Methylpyridine-2-carboxylic acid
  • SMILES O=C(O)C1=NC(C)=CC=C1

Description

6-Methylpicolinic acid offers a sterically accessible pyridine core with enhanced electron density at the ortho position, enabling efficient coordination in transition metal complexes. This bench-stable derivative facilitates ligand integration in catalytic systems requiring controlled donor strength and improved solubility in polar solvents.

Application

6-Methylpicolinic acid serves as a versatile building block in medicinal chemistry and catalysis, offering a robust pyridine core with ortho-methyl and carboxylic acid functionalities. Its defined electronic profile enables reliable coupling reactions, metal coordination, and derivatization for drug discovery applications. The compound exhibits excellent bench stability, ease of purification, and compatibility with standard synthetic protocols.

Synthesis

  • Route1

    References

    • US2005/124807 A1, ; Page/Page column 11 ;
  • Route2

    References

    • Zhong, Qi-Di; Xue, Yun-Zhou; Yan, Hong; Song, Xiu-Qing; Zhong, Ru-Gang Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 18 p. 5532 - 5535
  • Route3

    References

    • Chemical communications (Cambridge, England), , # 15 p. 1948 - 1949

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.08822
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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