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CS-W001157 4
Total: USD 88.00

2-Fluoro-5-bromobenzaldehyde

  • CAS No. 93777-26-5

  • Cat. No. CS-M3077
  • Purity≥96%
  • MDL No.MFCD00070755

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-5-bromobenzaldehyde|CS-M3077

Structure of 93777-26-5

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General Information

  • CAS No. 93777-26-5
  • Cat. No. CS-M3077
  • Purity ≥96%
  • MDL No. MFCD00070755
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄BrFO
  • Molecular Weight 203.01
  • Synonym(s) 5-Bromo-2-fluoro-benzaldehyde
  • SMILES O=CC1=CC(Br)=CC=C1F

Description

2-Fluoro-5-bromobenzaldehyde features a fluorinated aromatic ring paired with a bromine substituent at the para position relative to the aldehyde group. This combination imparts enhanced electron-withdrawing character and improved stability under standard handling conditions. The aldehyde functionality enables direct coupling in cross-coupling reactions, while the halogen atoms serve as reactive handles for further diversification via palladium-catalyzed transformations.

Application

2-Fluoro-5-bromobenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. Its orthogonal reactivity profile—combining electrophilic bromine and electron-withdrawing fluorine—facilitates selective transformations while maintaining bench stability and ease of purification.

Synthesis

  • Route1
    • null|null
      107-31-3
    • null|null
      460-00-4
    • ~52%
    • In-stock
      2-Fluoro-5-bromobenzaldehyde|CS-M3077
      93777-26-5

    References

    • FOVEA PHARMACEUTICALS; FEUTRILL, John; LERICHE, Caroline; MIDDLEMISS, David Patent: WO2013/37705 A2, 2013 ; Location in patent: Page/Page column 209; 210 ; WO 2013/037705 A2
  • Route2
    • null|null
      68-12-2
    • null|null
      460-00-4
    • ~81%
    • In-stock
      2-Fluoro-5-bromobenzaldehyde|CS-M3077
      93777-26-5

    References

    • Malancona, Savina; Colarusso, Stefania; Ontoria, Jesus M.; Marchetti, Antonella; Poma, Marco; Stansfield, Ian; Laufer, Ralph; Di Marco, Annalise; Taliani, Marina; Verdirame, Maria; Gonzalez-Paz, Odalys; Matassa, Victor G.; Narjes, Frank Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4575 - 4579
  • Route3

    References

    • US5489592 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.4007
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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