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CS-W001157 4
Total: USD 88.00

2,2-Difluoro-2-(4-fluorophenyl)acetic acid

  • CAS No. 94010-78-3

  • Cat. No. CS-0142443
  • Purity≥98%
  • MDL No.MFCD11167795

*For research and further manufacturing use only, not for direct human use.

2,2-Difluoro-2-(4-fluorophenyl)acetic acid|CS-0142443

Structure of 94010-78-3

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General Information

  • CAS No. 94010-78-3
  • Cat. No. CS-0142443
  • Purity ≥98%
  • MDL No. MFCD11167795
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅F₃O₂
  • Molecular Weight 190.12
  • Synonym(s) α,α,4-Trifluorobenzeneacetic Acid
  • SMILES O=C(O)C(F)(F)C1=CC=C(F)C=C1

Description

This difluorinated acetic acid derivative features a sterically constrained aryl-fluoride motif, delivering enhanced metabolic stability and lipophilic character. The para-fluorophenyl group imparts electron-withdrawing effects, while the geminal difluoro substitution enhances both chemical robustness and membrane permeability. Designed for incorporation into bioactive scaffolds requiring precise electronic modulation and resistance to oxidative degradation.

Application

2,2-Difluoro-2-(4-fluorophenyl)acetic acid serves as a stable, bench-ready building block for fluorinated aromatic motifs. Its difluoromethyl group enables direct incorporation into bioactive scaffolds via standard acylation and coupling reactions. The molecule exhibits excellent functional group tolerance and facilitates the synthesis of pharmaceutically relevant heterocycles and fluorinated ketones under mild conditions.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.0021
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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