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Structure of 94108-56-2
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4-(Trifluoromethoxy)benzenesulfonyl chloride features a strongly electron-withdrawing trifluoromethoxy group flanking a reactive sulfonyl chloride moiety. This combination enhances electrophilicity and reactivity in nucleophilic substitution, enabling efficient incorporation into sulfonamide derivatives. The molecule exhibits bench-stable handling characteristics under anhydrous conditions, facilitating use in synthetic workflows requiring precise functionalization.
4-(Trifluoromethoxy)benzenesulfonyl chloride serves as a robust sulfonylating agent for the efficient installation of trifluoromethoxy-substituted sulfonamide groups. Its stability under standard bench conditions and compatibility with diverse nucleophiles enable reliable synthesis of sulfonamide derivatives in medicinal chemistry workflows. Functions effectively in amine functionalization, enabling rapid access to bioactive scaffolds with enhanced metabolic stability and membrane permeability.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3265
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Lot numbers can be found on the outside label of a product: