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Structure of 944900-55-4
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4-(Trifluoromethyl)-1,3-thiazole-2-carboxylic acid features a strongly electron-deficient thiazole core augmented by a potent trifluoromethyl group, enhancing both metabolic stability and lipophilicity. This scaffold integrates readily into bioactive molecules, serving as a key building block in medicinal chemistry for targeted kinase inhibitors and receptor modulators.
4-(Trifluoromethyl)-1,3-thiazole-2-carboxylic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the thiazole carboxylic acid moiety enables direct coupling reactions for peptide and heterocyclic scaffold construction. The compound exhibits good bench stability, facilitates efficient purification, and functions reliably in standard amide bond formation and Suzuki-Miyaura cross-coupling protocols.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: