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Structure of 944903-05-3
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6-Bromoimidazo[1,2-a]pyrimidine-3-carboxylic acid is a heterocyclic building block featuring a bromine atom at the 6-position and a carboxylic acid group at the 3-position. This combination enables direct functionalization in cross-coupling reactions and facilitates conjugation to biomolecules or solid supports. The molecule exhibits good stability under standard conditions and serves as a key intermediate in medicinal chemistry campaigns targeting kinase inhibitors and nucleoside analogs.
6-Bromoimidazo[1,2-a]pyrimidine-3-carboxylic acid serves as a versatile building block for medicinal chemistry and heterocyclic synthesis. Its bromo group enables palladium-catalyzed cross-coupling reactions, while the carboxylic acid facilitates amidation, esterification, and derivatization. The imidazopyrimidine core provides structural rigidity and hydrogen-bonding capacity, enhancing target affinity in kinase inhibitors and other bioactive scaffolds. The compound exhibits good bench stability and is readily purified by standard chromatographic methods, making it suitable for scale-up and iterative library synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: