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Structure of 947-65-9
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Methyl 2-hydroxy-1-naphthoate is a bench-stable, moisture-tolerant ester featuring a strategically positioned hydroxyl group on the naphthalene core. This configuration enables direct functionalization at the ortho position relative to the carbonyl, facilitating efficient coupling reactions in synthetic routes to complex polycyclic architectures and bioactive molecule scaffolds.
Methyl 2-hydroxy-1-naphthoate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to naphthoic acid derivatives and substituted heterocycles. Its ortho-hydroxy ester functionality supports intramolecular cyclization and metal-catalyzed coupling reactions, while the methyl ester group offers straightforward manipulation via hydrolysis or reduction. The compound exhibits good bench stability and facilitates purification by crystallization or flash chromatography, making it well-suited for iterative synthesis workflows in medicinal chemistry and materials development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: