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CS-W001157 4
Total: USD 88.00

1-(Pyrazin-2-yl)ethanol

  • CAS No. 94777-52-3

  • Cat. No. CS-0154078
  • Purity≥98%
  • MDL No.MFCD12153748

*For research and further manufacturing use only, not for direct human use.

1-(Pyrazin-2-yl)ethanol|CS-0154078

Structure of 94777-52-3

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General Information

  • CAS No. 94777-52-3
  • Cat. No. CS-0154078
  • Purity ≥98%
  • MDL No. MFCD12153748
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O
  • Molecular Weight 124.14
  • Synonym(s) 1-Pyrazin-2-yl-ethanol
  • SMILES CC(C1=CN=CC=N1)O

Description

1-(Pyrazin-2-yl)ethanol features a pyrazine ring linked to a primary alcohol-bearing ethyl group, offering a versatile scaffold for medicinal chemistry. The molecule exhibits favorable solubility and stability under standard conditions, enabling seamless integration into synthetic workflows. This compound serves as a key building block for heterocyclic derivatives in drug discovery pipelines.

Application

1-(Pyrazin-2-yl)ethanol serves as a versatile building block in medicinal chemistry, enabling the construction of pyrazine-containing scaffolds via standard functional group transformations. Its bench-stable alcohol functionality facilitates straightforward derivatization, including oxidation to the corresponding aldehyde or carboxylic acid, and participates reliably in coupling reactions. The molecule exhibits good solubility and purification compatibility, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • Acetylpyrazine, ≥99%|CS-1269018
      22047-25-2
    • ~%
    • In-stock
      1-(Pyrazin-2-yl)ethanol|CS-0154078
      94777-52-3

    References

    • Journal of Organic Chemistry, , vol. 57, # 17 p. 4756 - 4761
  • Route2
    • null|null
      75-07-0
    • In-stock
      2-Iodopyrazine|CS-W004887
      32111-21-0
    • ~83%
    • In-stock
      1-(Pyrazin-2-yl)ethanol|CS-0154078
      94777-52-3

    References

    • Buron, Frederic; Ple, Nelly; Turck, Alain; Marsais, Francis Synlett, 2006 , # 10 p. 1586 - 1588
  • Route3

    References

    • US4638005 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P233-P260-P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.01
  • LogP   0.5299
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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