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Structure of 95727-86-9
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5-(Trifluoromethyl)picolinonitrile features a trifluoromethyl group at the 5-position of the picolinonitrile scaffold, enhancing electron deficiency and metabolic stability. This configuration enables direct incorporation into heterocyclic systems via nucleophilic substitution or transition-metal-catalyzed coupling, delivering functionalized pyridine derivatives with improved solubility and bioavailability.
5-(Trifluoromethyl)picolinonitrile serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and cyclization reactions. Its trifluoromethyl and nitrile groups provide strong electron-withdrawing character and orthogonal reactivity, enhancing functional group tolerance and facilitating downstream derivatization. The compound exhibits excellent bench stability and is readily purified by distillation or flash chromatography, making it well-suited for scalable synthesis and high-throughput screening workflows.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 3439
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H302-H312-H315-H319-H332-H335
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Precautionary Statements : P261-P280-P304+P340-P405-P501
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Lot numbers can be found on the outside label of a product: