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Structure of 959070-42-9
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Ethyl 4,6-dichloro-2-(methylthio)pyrimidine-5-carboxylate features a highly reactive pyrimidine core with orthogonal halogen and sulfide functionalities. This electron-deficient scaffold enables direct functionalization at C4 and C6 positions, facilitating efficient coupling reactions. The methylthio group enhances solubility and stability under standard bench conditions. This compound serves as a key intermediate in the synthesis of kinase inhibitors and antiviral agents.
Ethyl 4,6-dichloro-2-(methylthio)pyrimidine-5-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient construction of pyrimidine-based scaffolds. The dichloro substitution pattern facilitates sequential nucleophilic displacement reactions, while the methylthio group offers orthogonal reactivity for selective transformations. Its bench-stable nature and compatibility with standard coupling conditions make it ideal for medicinal chemistry campaigns requiring precise functionalization of core pyrimidine frameworks.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: