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cis-3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]cyclobutanemethanol

  • CAS No. 959749-93-0

  • Cat. No. CS-0049721
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

cis-3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]cyclobutanemethanol|CS-0049721

Structure of 959749-93-0

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General Information

  • CAS No. 959749-93-0
  • Cat. No. CS-0049721
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₄O₂Si
  • Molecular Weight 216.39
  • Synonym(s) cis-3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]cyclobutanemethanol - D10549
  • SMILES CC(C)(C)[Si](C)(C)O[C@@H]1C[C@H](CO)C1

Description

cis-3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]cyclobutanemethanol is a sterically hindered silyl-protected cyclobutane derivative featuring a bench-stable hydroxyl group. This molecule integrates a bulky tert-butyldimethylsilyl moiety that enhances stability and selectivity in synthetic transformations. The cis-configured ring system supports stereoselective functionalization, enabling efficient access to complex cyclic scaffolds in medicinal chemistry and natural product synthesis.

Application

cis-3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]cyclobutanemethanol serves as a stable, bench-ready building block for the synthesis of cyclobutane-containing scaffolds. The silyl ether protects the alcohol under standard conditions while enabling selective deprotection and functionalization. Its cis-configured cyclobutane ring provides defined stereochemistry for medicinal chemistry applications, and the molecule exhibits excellent stability during purification and storage.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   2.7791
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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