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CS-W001157 4
Total: USD 88.00

4-Ethynyl-1-(methylsulfonyl)piperidine

  • CAS No. 959918-30-0

  • Cat. No. CS-0628369
  • Purity≥95%
  • MDL No.MFCD26399772

*For research and further manufacturing use only, not for direct human use.

4-Ethynyl-1-(methylsulfonyl)piperidine|CS-0628369

Structure of 959918-30-0

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General Information

  • CAS No. 959918-30-0
  • Cat. No. CS-0628369
  • Purity ≥95%
  • MDL No. MFCD26399772
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₃NO₂S
  • Molecular Weight 187.26
  • Synonym(s) None
  • SMILES O=S(N1CCC(C#C)CC1)(C)=O

Description

4-Ethynyl-1-(methylsulfonyl)piperidine is a versatile synthetic intermediate featuring a terminal alkyne and a sulfonamide moiety. This combination enables efficient copper-catalyzed coupling reactions, facilitating the integration of complex molecular architectures in medicinal chemistry and chemical biology applications. The molecule exhibits excellent stability under standard conditions and offers high functional group tolerance.

Application

4-Ethynyl-1-(methylsulfonyl)piperidine serves as a versatile building block for the synthesis of bioactive heterocycles, enabling efficient Sonogashira coupling and click chemistry transformations. The terminal alkyne group facilitates conjugation with aryl halides or azide-containing systems, while the methylsulfonyl group enhances solubility and provides a handle for further functionalization. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for medicinal chemistry and process development workflows.

Safety Information

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Computational Chemistry Data

  • TPSA   37.38
  • LogP   0.2912
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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