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Ethyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate

  • CAS No. 96568-07-9

  • Cat. No. CS-0046189
  • Purity≥97%
  • MDL No.MFCD08458313

*For research and further manufacturing use only, not for direct human use.

Ethyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate|CS-0046189

Structure of 96568-07-9

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General Information

  • CAS No. 96568-07-9
  • Cat. No. CS-0046189
  • Purity ≥97%
  • MDL No. MFCD08458313
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₂ClFN₂O₃
  • Molecular Weight 310.71
  • Synonym(s) 1,8-Naphthyridine-3-carboxylic acid, 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, ethyl ester
  • SMILES O=C(C1=CN(C2CC2)C3=C(C=C(F)C(Cl)=N3)C1=O)OCC

Synthesis

  • Route1
    • null|null
      96568-06-8
    • ~99%
    • Ethyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate|CS-0046189
      96568-07-9

    References

    • YUHAN CORPORATION Patent: WO2004/56781 A1, 2004 ; Location in patent: Page 5-6 ;
  • Route2
    • null|null
      143879-85-0
    • ~19%
    • Ethyl 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate|CS-0046189
      96568-07-9
    • null|null
      143879-86-1

    References

    • Journal of Heterocyclic Chemistry, , vol. 29, # 4 p. 985 - 989
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 45, # 25 p. 5564 - 5575

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   61.19
  • LogP   2.7006
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   3

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