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CS-W001157 4
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5-Ethoxypicolinic acid

  • CAS No. 98353-08-3

  • Cat. No. CS-0039245
  • Purity≥98%
  • MDL No.MFCD13562922

*For research and further manufacturing use only, not for direct human use.

5-Ethoxypicolinic acid|CS-0039245

Structure of 98353-08-3

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General Information

  • CAS No. 98353-08-3
  • Cat. No. CS-0039245
  • Purity ≥98%
  • MDL No. MFCD13562922
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO₃
  • Molecular Weight 167.16
  • Synonym(s) 5-Ethoxy-2-pyridinecarboxylic acid
  • SMILES O=C(C1=NC=C(OCC)C=C1)O

Description

5-Ethoxypicolinic acid is a bench-stable, moisture-tolerant heterocyclic carboxylic acid featuring an ethoxy group at the pyridine ring’s 5-position. This substitution enhances solubility in polar organic solvents and facilitates direct incorporation into pharmaceutical intermediates via amidation or esterification. The electron-withdrawing nature of the carboxylate group modulates reactivity in synthetic transformations.

Application

5-Ethoxypicolinic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a pyridine ring with orthogonal functionalization at the 5-position. Its ethoxy group facilitates subsequent transformations such as hydrolysis, amidation, or cross-coupling reactions, while the carboxylic acid moiety supports efficient derivatization and purification via standard aqueous workups. The molecule exhibits good bench stability and functional group tolerance, making it well-suited for multi-step synthesis workflows targeting heterocyclic scaffolds and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   1.1785
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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