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Structure of 99548-54-6
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Methyl 3-bromo-2-methylbenzoate features a bromine atom at the meta position relative to the ester group, with a methyl substituent at the adjacent ortho site. This electron-deficient aromatic scaffold enables direct functionalization in cross-coupling reactions and serves as a key intermediate in pharmaceutical synthesis.
Methyl 3-bromo-2-methylbenzoate serves as a versatile ortho-heteroaryl building block for palladium-catalyzed cross-coupling reactions, enabling efficient access to substituted biaryls and complex aromatic scaffolds. The bromine substituent exhibits high reactivity in Suzuki, Stille, and Negishi couplings, while the methyl and ester groups provide orthogonal functional handles for further derivatization. Bench-stable and readily purified by flash chromatography, it functions reliably in multi-step syntheses requiring precise regiocontrol.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: