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Sorafenib impurity
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Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50 of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50 of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis and has anti-tumor activity. Sorafenib is also a ferroptosis agonist. ChemScene offers a range of Sorafenib impurities to meet customer filing requirements.
Sorafenib impurity
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