PEG Azide

PEG Azide is a click chemistry reagent, which is widely used in bioconjugation, labeling and chemical modification due to its mild reaction conditions, fast reaction speed and good biocompatibility. The azide group (N3) undergoes click chemistry with the alkyne group to form a stable triazole bond. For structurally constrained alkynes, such as BCN and DBCO, the reaction can be carried out without copper catalysis. The azide group is very attractive due to its high selectivity and stability under most conditions. , Especially when stability is limited or variables (such as pH) need to be strictly controlled to ensure high yield reactions, the advantages of the azide group are particularly prominent. PEG is hydrophilic and can improve the solubility of reagents and attached molecules. Selecting PEG of different lengths can also help to fine-tune the DMPK and other properties of the binding molecule.