Avanafil impurity

Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM, for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates the NO/cGMP/PKG signaling pathway, reducing bone density loss, bone atrophy and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis, thereby increasing cGMP levels. Avanafil can be used in the study of erectile dysfunction and osteoporosis. ChemScene offers a range of Avanafil impurities to meet customer filing needs.