Spirol Rings compounds

Refers to a polycyclic compound in which two single rings share one carbon atom. Compared with the planar aromatic structure, the spiro structure has a larger three-dimensional structure and a more novel structure. From the perspective of drugability, the drugability of a compound is reduced when there are too many planar aromatic ring structures in the compound structure. Introducing spiro into drug molecules is not only easier to obtain patent protection, but also helps to improve the stability of the compound and improve pharmacokinetic properties. Therefore, the application of spiro in drug design has gradually attracted the attention of medicinal chemists, and many drugs currently on the market contain spiro structures.