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CS-W001157 4
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1-(tetrahydro-2H-pyran-4-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

  • CAS No. 1040377-03-4

  • Cat. No. CS-W000813
  • Purity≥97%
  • MDL No.MFCD12033229
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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

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1-(tetrahydro-2H-pyran-4-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole|CS-W000813

Structure of 1040377-03-4

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Description

This pyrazole boronate ester integrates a tetrahydropyran-4-yl group and a stable diborane moiety, enabling efficient cross-coupling under mild conditions. The protected hydroxyl functionality enhances solubility and stability in aqueous and polar organic media. Designed for direct use in Suzuki-Miyaura reactions, it delivers high yields with minimal side-product formation.

Application

1-(Tetrahydro-2H-pyran-4-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole serves as a stable, bench-ready boronate building block for Suzuki-Miyaura cross-coupling reactions. The tetrahydro-2H-pyran-4-yl group provides excellent solubility and protection of the alcohol functionality, while the pinacol boronate enables efficient coupling with aryl, heteroaryl, and vinyl halides under mild conditions. Its high functional group tolerance and ease of purification make it ideal for constructing complex scaffolds in medicinal chemistry and materials science applications.

General Information

  • CAS No. 1040377-03-4
  • Cat. No. CS-W000813
  • Purity ≥97%
  • MDL No. MFCD12033229
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₃BN₂O₃
  • Molecular Weight 278.16
  • Synonym(s) 1-(Tetrahydro-pyran-4-yl)-1H-pyrazole-4-Boronic acid pinacol ester
  • SMILES CC1(C)OB(OC1(C)C)c1cnn(c1)C1CCOCC1

Computational Chemistry Data

  • TPSA   45.51
  • LogP   1.5338
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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