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CS-W001157 4
Total: USD 88.00

Adefovir

  • CAS No. 106941-25-7

  • Cat. No. CS-0013877
  • Molecule weightNone
  • Purity≥98%
  • MDL No.MFCD00866943

*For research and further manufacturing use only, not for direct human use.

Adefovir|CS-0013877

Structure of 106941-25-7

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General Information

  • CAS No. 106941-25-7
  • Cat. No. CS-0013877
  • Purity ≥98%
  • MDL No. MFCD00866943
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₂N₅O₄P
  • Molecular Weight None
  • Synonym(s) GS-0393; PMEA
  • SMILES NC1=C2N=CN(CCOCP(O)(O)=O)C2=NC=N1

Description

Inhibiting viral DNA synthesis through selective reverse transcriptase blockade, Adefovir (CAS 106941-25-7) demonstrates potent antiviral activity against hepatitis B and herpes simplex virus in clinical research models.

Application

Adefovir (CAS 106941-25-7) inhibits porcine endogenous retrovirus (PERV) replication by targeting reverse transcriptase activity in cell culture models, demonstrating potent antiviral efficacy against enveloped retroviral elements. It blocks viral DNA synthesis. Researchers use this mechanism to evaluate PERV suppression in xenotransplantation research.

Synthesis

  • Route1
    • Diethyl ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonate|CS-0441520
      116384-53-3
    • ~95%
    • In-stock
      Adefovir|CS-0013877
      106941-25-7

    References

    • Nucleosides and Nucleotides, , vol. 17, # 8 p. 1445 - 1451
  • Route2
    • null|null
      142340-94-1
    • ~97%
    • In-stock
      Adefovir|CS-0013877
      106941-25-7

    References

    • Green Chemistry, , vol. 14, # 8 p. 2282 - 2288
  • Route3

    References

    • Collection of Czechoslovak Chemical Communications, , vol. 52, # 11 p. 2801 - 2809

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   136.38
  • LogP   -0.4397
  • H_Acceptors   7
  • H_Donors   3
  • Rotatable_Bonds   5

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