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Structure of 1083246-26-7
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4-Cyclopropyl-1,2,5-oxadiazole-3-carboxylic acid features a stable oxadiazole core with a cyclopropyl substituent enhancing lipophilicity and metabolic resilience. This scaffold delivers a rigid, electron-deficient platform ideal for bioisosteric replacement in medicinal chemistry. The carboxylic acid group enables direct conjugation or salt formation, facilitating integration into peptide macrocycles and drug candidates requiring precise polarity modulation.
4-Cyclopropyl-1,2,5-oxadiazole-3-carboxylic acid serves as a stable, bench-accessible building block for heterocyclic synthesis. Its oxadiazole core exhibits enhanced metabolic stability and favorable polarity, enabling efficient incorporation into bioactive scaffolds. The carboxylic acid functionality facilitates direct coupling reactions or derivatization, supporting applications in medicinal chemistry and API development. Functions effectively in standard amide bond formation and transition-metal-catalyzed transformations with good functional group tolerance.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: