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CS-W001157 4
Total: USD 88.00

7-Fluoro-5-methoxy-1H-indole

  • CAS No. 1106942-47-5

  • Cat. No. CS-0530878
  • Molecule weight165.16
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Fluoro-5-methoxy-1H-indole|CS-0530878

Structure of 1106942-47-5

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General Information

  • CAS No. 1106942-47-5
  • Cat. No. CS-0530878
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈FNO
  • Molecular Weight 165.16
  • Synonym(s) 5-Methoxy-7-fluoro-1H-indole
  • SMILES FC1=CC(OC)=CC2=C1NC=C2

Description

7-Fluoro-5-methoxy-1H-indole features a fluorinated aryl ring paired with a methoxy substituent, delivering enhanced electron-withdrawing character and improved metabolic stability. This indole scaffold integrates readily into bioactive molecule design, particularly in kinase inhibitors and CNS-targeted pharmaceuticals. The ortho-fluorine enables strategic C–H functionalization, while the para-methoxy group supports solubility and target engagement.

Application

7-Fluoro-5-methoxy-1H-indole serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its electron-deficient aromatic core enhances reactivity in palladium-catalyzed transformations, while the methoxy group provides orthogonal handle for selective derivatization. Bench-stable and readily purified by flash chromatography, it facilitates efficient synthesis of indole-based pharmaceutical scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   25.02
  • LogP   2.3156
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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