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CS-W001157 4
Total: USD 88.00

1-Amino-2-methylpropan-2-ol

  • CAS No. 2854-16-2

  • Cat. No. CS-W008799
  • Molecule weight89.14
  • Purity≥95%
  • MDL No.MFCD01697283

*For research and further manufacturing use only, not for direct human use.

1-Amino-2-methylpropan-2-ol|CS-W008799

Structure of 2854-16-2

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General Information

  • CAS No. 2854-16-2
  • Cat. No. CS-W008799
  • Purity ≥95%
  • MDL No. MFCD01697283
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₁NO
  • Molecular Weight 89.14
  • Synonym(s) None
  • SMILES CC(O)(C)CN

Description

1-Amino-2-methylpropan-2-ol is a tertiary amine with a sterically hindered hydroxyl group, offering enhanced stability under standard conditions. This structure enables efficient incorporation into peptide-coupling protocols and facilitates the synthesis of protected amino acid derivatives without racemization.

Application

1-Amino-2-methylpropan-2-ol serves as a valuable scaffold in medicinal chemistry, offering a tertiary alcohol and primary amine functionality for derivatization. Its bench-stable nature and compatibility with standard coupling protocols facilitate efficient incorporation into bioactive molecules. The molecule functions effectively as a building block for heterocyclic systems and peptidomimetics, enabling diverse synthetic routes in API development.

Synthesis

  • Route1
    • null|null
      75-86-5
    • ~81%
    • In-stock
      1-Amino-2-methylpropan-2-ol|CS-W008799
      2854-16-2

    References

    • Kasai, Shizuo; Kamata, Makoto; Masada, Shinichi; Kunitomo, Jun; Kamaura, Masahiro; Okawa, Tomohiro; Takami, Kazuaki; Ogino, Hitomi; Nakano, Yoshihide; Ashina, Shuntarou; Watanabe, Kaoru; Kaisho, Tomoko; Imai, Yumi N.; Ryu, Sunghi; Nakayama, Masaharu; Nagisa, Yasutaka; Takekawa, Shiro; Kato, Koki; Murata, Toshiki; Suzuki, Nobuhiro; Ishihara, Yuji Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4336 - 4351
  • Route2
    • null|null
      558-30-5
    • ~69%
    • In-stock
      1-Amino-2-methylpropan-2-ol|CS-W008799
      2854-16-2

    References

    • Riker Laboratories, Inc. Patent: US4988815 A1, 1991 ;
  • Route3
    • null|null
      344868-41-3
    • ~96%
    • In-stock
      1-Amino-2-methylpropan-2-ol|CS-W008799
      2854-16-2

    References

    • Igarashi, Yasushi; Aoki, Katsuyuki; Nishimura, Hiroaki; Morishita, Isao; Usui, Kimitoshi Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 8 p. 1088 - 1091

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H227-H302-H315-H318-H335
Precautionary Statements : P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P403-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   -0.284
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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